Introduction : Beta thalassemia major is an autosomal recessive blood disorder. Thalassemia refers to a group of genetic disorders of globin chain production in which there is an imbalance between the α-globin and β-globin chain production. β-Thalassemia syndromes result from a decrease in β-globin chains, which results in a relative excess of α-globin chains. Material and Methods : Sample size : 45. Duration of Study: June 2016- June 2018. Children from 5 to 15 years of age who are diagnosed case of Beta thalassemia Major with blood requirement more than 200 ml/kg/year. The patients were divided into 2 groups: 5 to 10 years and 11 to 15 years. History and complete physical examination with haematological workup were done in all cases. Pre-transfusion haemoglobin of all 45 patients was noted. The risks and benefits of splenectomy were explained, 20 patients were selected for splenectomy. Result : From the Age group of 5 to 10 years there were Total 22 patients out of which 11 underwent splenectomy. The normal haemoglobin level in the children of this age group is 12.5 gm/dl on an average. The average haemoglobin level in non-splenectomised patients were 7 gm/dl. On the other hand the average haemoglobin level in a splenectomised patient was 9 gm/dl, 6 months after splenectomy. The annual blood requirement of all splenectomised and non-splenectomised patients was compared. In non splenectomised patients the annual requirement was 260 ml/kg/year while in splenectomised patients it was 210 ml/kg/year. Conclusion : The mean haemoglobin levels were on a higher side in splectomized patients as compared to their pre-operative levels as well as compared to non-splenectomized patients. The blood requirement significantly reduced in splenectomized patients to 210 ml/kg/year.
Keyword : Thalassemia Major, Splenectomy, Blood transfusion.
Authors: Dr. Prajakta Ghatage, Dr. Ramesh Kothari, Dr. Sunil Mhakse
VIMS Health Sci Journal: 2018; 5 (4):164-166 | PDF Full Article |
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