AirwayAntioxidant Capacity In Adenosine – Signaling Pulmonary Fibrosis In Lung Disease Patient

Authors:   Dr. Mrs. Anita M Raut, Dr A.N. Suryakar ,Dr. Mrs. Smita D. Mhaisekar, Dr. DilipMhaisekar.

VIMS Health Sci Journal:  2014, 1 (2) | Abstract | pdf PDF Full Article | DOI:

Abstract:

Background – Pulmonary fibrosis is a common feature of numerous lung disorders, including interstitial lung diseases, asthma, and chronic obstructive pulmonary disease. Adenosine is a purine-signaling nucleoside that is generated in excess during cellular stress and damage. This signaling molecule has been implicated in the regulation of features of chronic lung disease; however, the impact of adenosine on pulmonary fibrosis is not well understood. Objective-The goal of this study was to explore the impact of endogenous adenosine elevations on pulmonary fibrosis and to compare ADA activity with total antioxidant capacity in lung disease patients. Materials and Method- : In the present study 100 healthy non-smokers were served as controls and 60 patients with lung fibrosis were included. Their baseline clinical examination Total antioxidant capacity and adenosine deaminase levels were measured. The adenosine deaminase (ADA) activity in the patients at base line was high (P< 0.001) than controls. The total antioxidant capacity (TAC ) was low (P<0.001) in the lung fibrosis patient compared to controls. Conclusion-These findings demonstrate the adenosine signaling with chronic adenosine elevations was associated with pulmonary fibrosis in lung disease patient with decreased total antioxidant capacity.

Key words:  Adenosine deaminase , lung fibrosis,Total antioxidant capacity , Adenosine receptor.

How to Cite:

Vancouver/ICMJE Style

 RautA M, Suryakar A N, Mhaisekar, S D, Mhaisekar. D.AirwayAntioxidant Capacity In Adenosine – Signaling Pulmonary Fibrosis In Lung Disease Patient,VIMSHSJ,(2014),1(2), pp-6-9

 Harvard Style

RautA M, Suryakar A N, Mhaisekar, S D, Mhaisekar. D(2014),AirwayAntioxidant Capacity In Adenosine – Signaling Pulmonary Fibrosis In Lung Disease Patient,VIMS Health Science Journal(VIMSHSJ),1(2), pp-6-9

APA (American Psychological Association) Style

RautA M, Suryakar A N, Mhaisekar, S D, Mhaisekar. D(2014),AirwayAntioxidant Capacity In Adenosine – Signaling Pulmonary Fibrosis In Lung Disease Patient,VIMS Health Science Journal(VIMSHSJ),1(2), pp-6-9