To study the effect of Pretreatment with Lidocaine and Diclofenac in Reducing Succinylcholine induced Myalgia

Authors: Pandey. A. K, Sunil Kumar. V, Saraf. R, Kale. S.

VIMS Health Sci Journal:  2014, 1 (1) | Abstract | pdf PDF Full Article | DOI:

Abstract -

Background: Succinylcholine, a depolarizing muscle relaxant, known for its rapid onset of action and fast emergence, is the preferred muscle relaxant for ambulatory anaesthesia, short surgical procedures and rapid sequence induction as it provides almost ideal intubating conditions. Postoperative myalgia is a minor but frequent adverse effect of succinylcholine administration. It prolongs hospital stay and increases the cost of treatment- a demerit in day care surgery. Several drugs like lidocaine, rocuronium, diazepam & NSAIDS have been observed to decrease the incidence and severity of post operative myalgia, lidocaine and diclofenac being the safer of these drugs. The purpose of this study is to compare the effect of pretreatment with intravenous lidocaine versus intramuscular diclofenac in succinylcholine induced post operative myalgia.

Material And Methods : 120 consenting adult inpatients of Padmashree Dr. Vithalrao Vikhe Patil Medical College Hospital who were posted for elective minor surgery, under general anaesthesia, between the age group of 18-50 years with ASA physical status I and II were selected for the study. They were further divided into three groups of 40 each: Group D- to receive 75 mg intramuscular diclofenac. pretreatment, Group L – intravenous lidocaine 1.5 mg/kg and Group C – the controls. Patients were preoxygenated and induced with 5mg/kg IV thiopentone sodium followed by 1.5 mg/kg IV of succinylcholine. The presence and degree of fasciculation were assessed visually on a four point scale. The severity and intensity of post operative myalgia were assessed by the investigator with a standardized questionnaire 1 hour, 24 hours and 48 hours after surgery. Results : IV lidocaine showed a statistically significant (p<.016) reduction in the incidence and intensity of succinylcholine induced myalgia. IM diclofenac showed no such reduction when compared to the control group. When compared to diclofenac, lidocaine proved to be more efficacious in reducing the incidence and intensity of pain at all of the three time points. Conclusion : Intravenous lidocaine is effective in the prevention of postoperative succinylcholine induced myalgia.

Key words : Succinylcholine, myalgia, lidocaine, diclofenac, fasciculations

How to Cite:

Vancouver/ICMJE Style

 Pandey. A. K, Sunil Kumar. V, Saraf. R, Kale. S., To study the effect of Pretreatment with Lidocaine and Diclofenac in Reducing Succinylcholine induce Myalgia, VIMSHSJ,(2014),1(1),pp-17-22.

Harvard Style;

 Pandey. A. K, Sunil Kumar. V, Saraf. R, Kale. S (2014), To study the effect of Pretreatment with Lidocaine and Diclofenac in Reducing Succinylcholine induce Myalgia ,VIMS Health Science Journal(VIMSHSJ),1(1), pp-17-22.

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APA (American Psychological Association) Style:

Pandey. A. K, Sunil Kumar. V, Saraf. R, Kale. S (2014), To study the effect of Pretreatment with Lidocaine and Diclofenac in Reducing Succinylcholine induce Myalgia, VIMS Health Science Journal(VIMSHSJ),1(1), pp-17-22.