Evaluation of Nephroprotective Activity of Shilajit In Gentamicin Induced Nephrotoxicity
PDF Downloads : 19    VIEW PDF

Keywords

Shilajit
Gentamicin
Nephrotoxicity

How to Cite

Pagar , M. H. J. . . . . . . . . . . . . . ., Raman, M. T. . . . . . . . . . . . . . . . . . ., & Gaikwad, D. P. M. . (2017). Evaluation of Nephroprotective Activity of Shilajit In Gentamicin Induced Nephrotoxicity. VIMS Health Science Journal , 4(1), 10-15. Retrieved from https://www.vimshsj.edu.in/index.php/main/article/view/114

Abstract

Gentamicin is an aminoglycosidal antibiotic widely used in treating severe gram negative infections. However its limited used due to renal dysfunction. The present investigation was carried out to evaluate the nephroprotective activity of Shilajit in gentamicin induced nephrotoxicity. Shilajit (200, 400 and 800 mg/kg p.o.) was administrated for 8 days. Gentamicin was administrated at the dose of 80mg/kg i.p. daily from 4th to 10th day. Gentamicin (alone) treated group showed increased levels of urine and serum urea, creatinine, uric acid, potassium and decreased levels of urine and serum sodium levels, which were significantly retrieved in group pre-treated with Shilajit (400 & 800mg/kg p.o.) where as Shilajit (200mg/kg p.o.) showed insignificant results. The antioxidant activity of Shilajit revealed that the level of urine and serum in Shilajit pre-treated group when compared with gentamicin alone treated group. The histopathological analysis also showed the protective nature of Shilajit in Gentamicin induced renal damage. The main goal of this paper is to provide an actualized and mechanistic vision of pathways involved in glomerular toxic effects of Gentamicin.

PDF Downloads : 19    VIEW PDF

References

Durvasu J., Mondi S., Kondlepu H., Raghavendar R., Chidrawar V., Maheswara Rao U. ‘A Comprehensive Review on Nephroprotective Medicinal Plants’. Int. J. Inv Pharm. Sci. (2014);2(3): 759.

Asangansi i.E, Oshin A.O., Akinloye A.O. "Drug Nephrotoxicity. Ifemed Journal of Medicine, (2005).

Mohana Lakshmi S, Usha Kiran Reddy. T. Sandhya Rani. Ks. "A Review on Medicinal Plants for Nephroprotective Activity”. Asian J Pharm Clin Res. (2012):5(4): 8-14.

Nazeem Fahamiya, Mohd. Aslam. et.ai. ‘Nephroprotective activity of Methanolic Extract of Cucumis Melo Linn, in Gentamicin induced Nephrotoxicity”.

IJDFR. (2012):3(2): 40-53.

V.Chinnapa Reddy, V. Amulya, et al. "Effect of simvastatin in Gentamicin induced Nephrotoxicity in Albino Rats Asian J Pharm Clin Res (2011):5(1): 36-40.

Carlos Martinez-Salgado, Francisco J. Lopez- Hernandez, Jose M,. Lopez-Novoa. “Glomerular nephrotoxicity of aminoglycosides. “Toxicology and Applied Pharmacology. (2007): 223;86-98.

Wilson E, Rajamanickam GV, et.al. "Review on Shilajit used in traditional indian medicine”. J Ethnopharmacol.

(2011); 136(1):1-9.

Harsahay Meena, H. K. Pandey, M. C. Arya, and Zakwan Ahmed. “shilajit: A panacea for high-altitude problems”. Int J Ayurveda Res. (2010); 1(1):37-40.

Suraj P. Agarwal, Rajesh Khanna, Ritesh Karmarkar, Md. Khalid Anwer and Roop K. Khar. Shilajit: A Review”. Phytother. Res. (2007); 21, 401-405.

B. Vivek, E. Wilson, S.V. Nithya Devi, C. VeImurugan, M. Kannan. Cardioprotective activity of Shilajit in isoproterenol - induced myo-cardial infarction in rats: A biochemical and histopathological evaluation;. Int. J. Res. Phytochem. Pharmacol.(2011); 1(1):28-32.

Kalluru Bhargavi, N Deepa Ramani, Janarthan M, Duraivel S Evaiuation of nephroprotective activity of methanolic extract of seed of vitis vinifera against Rifampicin and carbon tetra chloride induced nephrotoxicity in wister rate”. India Journal of research in pharmacy and biotechnology. (2013);1(6):803-807.

M Gowrisri, Vikram Kumar Shetty et.al.”Anti-oxident and Nephropreotective Activites ofcassia Occidentails Leaf Exract against Gentamicin Indouced Nphrotoxicity in Rats Research Journal of Pharmaceutical, Biological and Chemical Sciences. (2012);3(3);684-694.

S. Vidya, A. Ramesh, G. Rajashekar, D. meghana, S. K. Nazeer. The Nephroprotective Activity of Methonolic Extacts of Phyllanthus Acidus Leaves against Gentamycin-Induced Nephrotoxicity in experimental Rodents”. international journal of phermacy and Pharmaceutical sciences. (2013);5(4)209-213,

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Downloads

Download data is not yet available.
https://pppi.sulselprov.go.id/-/slot-gacor/https://izv-tn.tti.sfedu.ru/-/slot-pulsa/http://dopovidi-nanu.org.ua/sites/default/files/slot-gacor/https://chasopys-ppp.dp.ua/public/site/slot-deposit-pulsa/https://www.ncst.mw/wp-content/uploads/slot-online/https://malawidiaspora.gov.mw/slot-deposit-pulsa/https://dopovidi-nanu.org.ua/ojs/styles/situs-slot-gacor/http://ojs3.bkstm.org/public/journals/1/togel-online/http://revistaaristas.tij.uabc.mx/public/link-slot-gacor/https://penerbit.undip.ac.id/pages/slot-deposit-pulsa/https://jurnal.madiunkab.go.id/pages/slot-gacor-4d/https://jurnal.madiunkab.go.id/public/site/slot-gacor-4d/https://perizinan.jambikota.go.id/frontend/web/slot-online/https://aar-healthcare.com/ke/wp-content/slot-dana/https://jurnal.madiunkab.go.id/pages/slot-gacor/http://ejournalbidan.poltekkes-kaltim.ac.id/slot-gacor-maxwin/https://sitenar.madiunkab.go.id/public/-/slot88/https://pendidikanbahasaindonesia.umnu.ac.id/-/slot-dana/https://perizinan.jambikota.go.id/frontend/web/slot/https://siagaki.sulselprov.go.id/frontend/slot88/https://peternakan.umnu.ac.id/-/slot-deposit-pulsa/https://datadesacenter.dpmd.jatimprov.go.id/puem/assets/https://datadesacenter.dpmd.jatimprov.go.id/assets/slot-pulsa/https://amerta.kemenkumham.go.id/file/slot-demo/https://www.ufrgs.br/nupegem/wp-content/slot-gacor/https://www.ufrgs.br/nupegem/slot-pulsa/https://188.166.227.65/http://prosiding.fisip.unsri.ac.id/-/slot-gacor/https://penerbit.undip.ac.id/-/slot-gacor/http://jurnal.amy.ac.id/public/-/slot-gacor/https://sipenta.bappeda.tulungagung.go.id/storage/slot-online/https://jurnalpangriptav3.malangkota.go.id/pages/slot-gacor-maxwin-4d/https://jurnalpangriptav3.malangkota.go.id/js/slot-deposit-pulsa-terpercaya/http://prosiding.fisip.unsri.ac.id/pages/slot-pulsa-terpercaya/http://prosiding.fisip.unsri.ac.id/js/slot-dana/https://kecamatanrancabali.bandungkab.go.id/public/css/slot-deposit-pulsa/https://jurnalpangriptav3.malangkota.go.id/demo-slot/https://jurnalpangriptav3.malangkota.go.id/-/joker123/http://prosiding.fisip.unsri.ac.id/pages/slot-bonus-100/https://jurnalpangriptav3.malangkota.go.id/styles/sv388/https://www.ufrgs.br/rbml/styles/slot-demo/https://kec-girimaya.pangkalpinangkota.go.id/-/slot-gacor/https://stisnu-aceh.ac.id/wp-content/uploads/2022/10/togel-online/https://ptik.unp.ac.id/wp-content/slot-deposit-pulsa/https://www.ufrgs.br/rbml/-/bola88/https://siagaki.sulselprov.go.id/frontend/slot-gacor/https://siagaki.sulselprov.go.id/frontend/slot-online/https://paper.icprp.uii.ac.id/public/togel-online/https://jescee.universitaspertamina.ac.id/pages/slot-dana/https://wirausaha.deliserdangkab.go.id/https://www.ufrgs.br/rbml/pages/pragmatic88/https://kecamatanrancabali.bandungkab.go.id/public/css/slot-online/https://paper.icprp.uii.ac.id/public/slot88/https://jurnalergonomik3.ti.itb.ac.id/js/https://penerbit.undip.ac.id/js/slot-deposit-pulsa/https://paper.icprp.uii.ac.id/public/slot-deposit-pulsa/https://penerbit.undip.ac.id/styles/slot/https://subdomainmaker.deliserdangkab.go.id/-/slot-gacor/https://ptik.unp.ac.id/wp-content/themes/slot-pulsa/https://paper.icprp.uii.ac.id/public/slot-gacor-maxwin/https://www.kecamatankutawaringin.bandungkab.go.id/public/slot777/http://prosiding.fisip.unsri.ac.id/pages/link-slot-gacor/https://dcs-ditkapel.dephub.go.id/storage/slot-deposit-pulsa/https://dcs-ditkapel.dephub.go.id/storage/slot-dana/https://www.ufrgs.br/nupegem/slot-pulsa/