Prevalence of Ophthalmological Manifestations In Patients Hospitalized for Dengue Fever – A Three Year Prospective Study

Authors

  • Dr. Avinash Mishra

Keywords:

Dengue, Ophthalmological manifestations, Visual prognosis

Abstract

Aim: of this study  was to record the various ophthalmological manifestations as well as visual prognosis in 212 cases of dengue fever who were admitted to this centre. Material & Methods: all patients who were admitted as serologically confirmed cases of dengue were subjected to a complete and detailed ophthalmologic examination, immaterial of the presence of any ocular complaints. Results: out of total 212 patients admitted with dengue, ophthalmic manifestations were seen in 94 (44.34%) patients. The youngest patient was 3 year old and the oldest was 69 years with the mean age being 27 year. A majority of the patients 52 (55.32%) were males, 8 (8.51%) patients initially presented with ophthalmic manifestations as the first sign of dengue. Anterior segment findings were far more common with subconjunctival haemorrhage seen in 38 (40.43%) patients, being the commonest ocular manifestation. Most of the patients showed a complete visual recovery within 3 months, however in 6 patients (6.38%), 8 eyes the vision recovered only partially with the final visual acuity being less than 6/12 even after 1 year of follow up. Conclusion: Ocular manifestations in dengue are relatively common. Sometimes they might be its only presenting sign. Hence it becomes imperative to be aware of these subtle signs and symptoms and always keep a dengue etiology in mind while dealing with such patients.

Downloads

Download data is not yet available.

References

Ramamurthy P, Venugopal K, Mudegoudara Lingaraja, Kushal D. P, Manjunath Ganiger, Sunil Kumar N. “ Bilateral Intraocular Haemorrhage: Rare and only Manifestation of Dengue Fever”. Journal of Evolution of Medical and Dental Sciences 2014 Oct; 3(53): 12382-12385.

Bacsal KE, Chee SP, Cheng CL, Flores JV. Dengue-associated maculopathy. –Arch Ophthalmol. 2007 Apr; 125(4): 501-10.

WHO. Dengue guidelines for diagnosis, treatment, prevention and control. Geneva: World Health Organization, 2009.

Lim WK, Mathur R, Koh A, Yeoh R, Chee SP. Ocular manifestations of dengue fever. Ophthalmology. 2004 Nov; 111(11): 2057-64.

Deparis X, Marechal V, Matheus S. [Pathophysiological mechanisms of dengue fever: critical review of current concepts]. Med Trop (Mars). 2009 Aug; 69(4): 351-7.

Ranjan S, Ranjan R. Dengue-related ocular pathology: A review. Int Jour of Biomed Res. 2013 Sep; 4(9): 451-460.

Verma R, Sahu R, Holla V. Neurological manifestations of dengue infection: a review. J Neurol Sci. 2014 Nov 15; 3461(1-2):26-34.

Pinheiro FP, Corber Sj. Global situation of dengue and dengue haemorrhagic fever, and its emergence in the Americas. –World Health Stat Q. 1997;50(3-4): 161-9.

Park K editor. Park’s textbook of preventive and social medicine. 18th edition. Jabalpur; Banarsidas Bhanot Publishers; 2005; 198-201.

World Health Organization. Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control. 2nd ed. Geneva, Switzerland: WHO; 1997.

Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ et al. Dengue: a continuing global threat. Nat Rev Microbiol. 2010 Dec; 8(12 Suppl): S7-16.

Ng AW, Teoh SC. Dengue eye disease. Surv Ophthalmol. 2015 Mar-Apr; 60(2):106-14.

Lifson AR. Mosquitoes, models, and dengue. –Lancet. 1996 May 4; 347(9010): 1201-2.

Bhaumik S. Study estimates 390 million dengue cases a year in world, with India having highest burden. BMJ. 2013 Apr 12; 346: f2339.

Mariapp an T. Current emerging situation of denguein India. Trop Doct. 2013 Jul; 43(3): 116-9.

Yip VC, Sanjay S, Koh YT. Ophthalmic complications of dengue Fever: a systematic review. Ophthalmol Ther. 2012 Dec;1(1):2.

Cruz-Villegas V, Berrocal AM, Davis JL. Bilateral choroidal effusions associated with dengue fever.-Retina. 2003 Aug; 23(4): 576-8.

Gupta A, Srinivasan R, Setia S, Soundravally R, Pandian DG. Uveitis following dengue fever. Eye (Lond). 2009 Apr; 23(4): 873-6.

Su DH, Bacsal K, Chee SP, Flores JV, Lim WK, Cheng BC et al. Prevalence of Dengue Maculopathy in Patient Hospitalized for Dengue Fever. Ophthalmology. 2007 Sep; 114(9): 1743-7.

Chan DP, Teoh SC, Tan CS, Nah GK, Rajagopalan R, Prabhakara Gupta MK et el. Ophthalmic complications of dengue. Emerg Infect Dis. 2006 feb; 12(2): 285-9.

Kanungo S, Shukla D, Kim R. Branch retinal artery occlusion secondary to dengue fever. –Indian J Ophthalmol. 2008 Jan-Feb; 56(1): 73-4.

Loh BK, Bacsal K, Chee SP, Cheng BC, Wong D. Foveolitis associated with dengue Fever: a case series. Ophthalmologica. 2008;222(5):317-20.

Seet RC, Quek AM, Lim EC. Symptoms and risk factors of ocular complications following dengue infection. J Clin Virol. 2007 Feb; 38(2): 101-5.

Chang PE, Cheng CL, Asok K, Fong KY, Chee SP, Tan CK. Visual disturbances in dengue fever: an answer at last? Singapore Med J 2007;48(3): e71-3.

Shivanthan MC, Ratnayake EC, Wijesiriwardena BC, Somaratna KC, Gamagedara LK. Paralytic squint due to abducens nerve palsy: a rare consequence of dengue fever. BMC Infect Dis. 2012 Jul 16; 12: 156.

Saranappa S B S, Sowbhaggya HN. Panophthalmitis in dengue fever. Indian Padiatr. 2012 Sep;49(9):760.

Donnio A,Beral L, Olindo S, Cabie A, Merle H. [Dengue, a new etiology in oculomotor paralysis]. Can J Ophthalmol. 2010 Apr;45(2):183-4.

Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC. Immunopathogenesis of dengue virus infection. J Biomed Sci 2001;8(5):377-8.

Kapoor HK, Bhai S, John M, Xavier J. Ocular manifestations of dengue fever in an East Indian epidemic. – Can J Ophthalmol. 2006 Dec;41(6):741-6.

Teoh Sc, Chee CK, Laude A, Goh KY, Barkham T, Ang BS; Eye Institute Dengue-related ophthalmic Complications Workgroup. Optical coherence tomography patterns as predictors of visual outcome in dengue-related maculopathy. Retina. 2010 Mar;30(3):390-8.

Khairallah M, Jelliti B, Jenzeri S. Emergent infectious uveitis. Middle East Afr J Ophthalmol. 2009 Oct;16(4):225-38.

Teoh SCB, Chan DPL, Nah GKM, et al; The Eye Institute Dengue-Related Ophthalmic Complication Workgroup. A relook at ocular complications in DF and dengue haemorrhagic fever. Dengue Bull 2006;30:184-190.

Downloads

Published

2016-09-15

How to Cite

Mishra, D. A. (2016). Prevalence of Ophthalmological Manifestations In Patients Hospitalized for Dengue Fever – A Three Year Prospective Study. VIMS Health Science Journal, 3(3), 104–110. Retrieved from https://www.vimshsj.edu.in/index.php/main/article/view/144

Issue

Section

Articles